One in eight American women are diagnosed with breast cancer today. Most breast cancers diagnosed are invasive breast cancers (also called infiltrating breast cancer). This means that the cancer starts in the milk ducts or lobules of the breast, and the cancer cells invade, or break through, the walls where they originated and spread into the surrounding breast tissue. It is uncertain what causes breast cancer but many studies point to a combination of factors, such as age, genetic predisposition, family history, lifestyle behaviors, reproductive factors, and environment.
The most common types of invasive breast cancers are invasive ductal and invasive lobular carcinomas.
Invasive carcinomas will be treated based on the stage and prognostic factors of the tumor.
Breast Imaging
Imaging tests such as a mammogram, ultrasound, and breast MRI take pictures of the inner part of your breast(s) so that a radiologist, a doctor that specializes in reading images, can take a closer look at your body.
Breast Biopsy
A breast biopsy is the only diagnostic procedure that can definitively confirm or rule out a breast cancer diagnosis.
When a suspicious mass or an area of concern is seen on a mammogram or ultrasound, your doctor will order a breast biopsy to have a sample of the tissue examined to check for the presence of cancer cells.
After the tissue from the breast biopsy is removed, it is sent to a lab where a pathologist, a doctor that specializes in analyzing body tissue, examines the cells under a microscope and determines a diagnosis. The pathologist will interpret the tissue samples and prepare a report to share with the healthcare team.
The pathology report will contain some of the following information about the diagnosis:
After a breast cancer diagnosis is confirmed, you will meet with a team of physicians that specialize in diagnosing and treating cancer, to discuss your treatment options.
The type and order of treatment options will vary based on your unique situation and can include one or more of the following:
Your cancer specialists will work together to determine the best combination of treatments for you based on their findings. They will take into consideration factors such as your age, overall health status, type of breast cancer and the stage of your disease.
Surgery
Surgery is a common treatment that is offered for early stage and locally advanced breast cancer. (Surgery is typically not done for stage IV breast cancers). When speaking with your surgeon, you will learn about the different surgical options that are recommended for you.
These recommendations will be based on many factors:
Two of the main types of breast cancer surgeries are called partial mastectomy (also called lumpectomy) and mastectomy, which are performed by a surgeon. If you choose to have a mastectomy, you will have the option to have reconstruction surgery, which is performed by a plastic surgeon.
Partial Mastectomy or Lumpectomy
A partial mastectomy, also called lumpectomy, segmental mastectomy or quadrantectomy, is considered breast-conserving surgery (BCS). During surgery, the surgeon removes the tumor and a margin of surrounding healthy breast tissue. The goal of a partial mastectomy is to remove the tumor with negative margins, determine if the tumor has spread to lymph nodes, and to preserve the appearance and shape of the breast.
Axillary staging, a biopsy of underarm lymph nodes, is most often done in patients using a technique called sentinel lymph node mapping. (See “Types of Axillary Surgery”).
Mastectomy
A mastectomy is a surgical procedure involving the complete removal of the breast. Axillary staging, a biopsy of underarm lymph nodes, is done in most patients often using a technique called sentinel lymph node mapping. The goal of a mastectomy is the complete removal of the breast, removal of the underlying tumor with negative margins, and to determine if the tumor has spread to lymph nodes.
Following a mastectomy, a small amount of breast tissue will remain within the fatty tissue below the skin. The amount of breast tissue left behind is influenced by the type of mastectomy performed.
Mastectomies can be categorized into several different types:
Most insurance companies will cover the cost of mastectomy bras, breast forms, camisoles and prosthesis. Ask your surgeon to write a prescription for these medically necessary supplies.
Breast Reconstruction Surgery
Breast reconstruction surgery is a treatment option for you to consider if you choose a mastectomy. This procedure is done by a plastic surgeon, a physician who specializes in reconstructing the breast mound after a mastectomy.
The goal of breast reconstruction surgery is to restore your breast(s) appearance and help you feel better about your body and the way you look in clothing after having a mastectomy. The plastic surgeon will talk to you about your treatment options, all the while, keeping in mind your lifestyle and personal preferences.
The two main types of reconstructive surgery are breast implants and autologous reconstruction (using your own tissue to rebuild the breast mound). Keep in mind that every woman’s circumstance is different and recovery times post-surgery can vary greatly based on the type of surgery you choose.
Types of Axillary Surgery
The axillary lymph nodes, lymph nodes located in the underarm area, are among the first places that invasive breast cancer spreads. Your surgeon will recommend a sentinel lymph node biopsy during surgery.
Sentinel lymph node mapping - radioactive dye is injected into the skin of the breast prior to surgery (can be done the day before surgery or several hours before surgery)
The goal of sentinel lymph node mapping is to accurately stage the axilla while limiting the extent of axillary surgery, thereby minimizing the risk of lymphedema (swelling of the arm area).
*Talk to your surgeon to learn more about lymph node removal during surgery.
Does Surgery Choice Affect Recurrence Rates?
A common dilemma that women face after a breast cancer diagnosis is deciding on the type of surgery to have in order to give them the best chance that the cancer will not recur.
Regardless of your surgery choice, long-term survival rates are the same, and local recurrence rates remain about the same when the standard of care is followed and are influenced by the following tumor characteristics such as the grade, size of the tumor and margin status.
In general, the risk of recurrence with the breast is as follows:
Partial Mastectomy or Lumpectomy
Mastectomy
Nationally, the most common type of treatment for women with DCIS is a partial mastectomy followed by radiation therapy and endocrine therapy if the tumor is estrogen receptor positive.
Your healthcare team can help create a plan that is specific for you based on your medical history, tumor characteristics, and personal feelings.
After receiving a breast cancer diagnosis, you can expect to see a medical oncologist at some point in your treatment plan. The medical oncologist has extensive knowledge in diagnosing and treating cancer and pays special attention to the pathology report(s) from your breast biopsy(s) and surgical pathology.
The information in the pathology report(s) helps the physician determine the best treatment option for the patient. In addition, the medical oncologist will discuss the risk of your cancer coming back after you have completed treatment.
Sometimes, additional testing (such as imaging, tissue sampling, or genetic testing) will be needed to gather more information about your disease before a treatment plan can be established.
Once your treatment plan is established, the medical oncologist will recommend the medication(s) most beneficial to you. The medication is considered “systemic treatment,” because it affects the entire body, not just the breast.
The goal of systemic treatment is to kill cancer cells and reduce the risk of cancer coming back in the breast and in other parts of the body, such as the organs and bones.
Hormone Blocker or Endocrine Therapy
A hormone blocker or endocrine therapy is prescribed for hormone receptor positive tumors and is a type of “systemic treatment,” meaning it affects the entire body, not just the breast.
The goal of a hormone blocker is to kill cancer cells and reduce the risk of recurrence:
The medication comes in pill form and is taken daily for five years. However, some patients may benefit from taking the medication for 10 years or more, depending on the circumstances. A medical oncologist will help determine which medication is best for you based on your medical history, stage of disease and menopausal status.
Hormone-blockers are typically prescribed after local treatment (surgery or radiation therapy) has been completed. In some circumstances, a physician may prescribe the medication sooner if surgery is delayed or the disease has spread to other organs (not likely with DCIS). Patients who undergo a bilateral mastectomy may be able to avoid endocrine therapy post-surgery. Talk to your medical oncologist to see what option is best for you.
If your pathology report indicates that your cancer is hormone receptor positive, your medical oncologist will determine which medication is most beneficial to you based on your medical history and menopausal status.
Two types of hormone-blockers are:
There are medications that can block the anti-cancer effectiveness of hormone-blockers so talk to your medical oncologist about what medications to avoid while on treatment.
Side Effects of Hormone Blockers
An endocrine therapy, such as tamoxifen and aromatase inhibitors, is prescribed for hormone sensitive breast cancers and is generally well-tolerated.
Side effects can vary from person to person*. In some cases, your body may just need to adjust to the medication and symptoms subside with time. In other cases, taking the medication at a different time of the day can ease side effects.
*Not all side effects are listed above. For information on the possible side effects of hormone blockers, ask about the “Managing Side Effects of Endocrine Therapy” handout and/or visit www.chemocare.com.
Chemotherapy
Chemotherapy is an anti-cancer medication that is either infused intravenously or given orally (by mouth) to fight cancer. The medication affects you systemically, traveling throughout the body to kill cancer cells.
Chemotherapy is not indicated for all breast cancer patients, especially those with an early stage disease with favorable prognostics.
Your physician will weigh many factors to determine if you will need chemotherapy or not:
If your medical oncologist feels you are a candidate for chemotherapy, the timing of the treatment can vary based on many factors:
Side Effects of Chemotherapy
There are a variety of different chemotherapy drugs available today for breast cancer treatment. Each drug has its individual list of possible side effects and they can be short-term or long-term, depending on the type and dosage of the drug(s) you receive.
The goal of chemotherapy is to kill the fast-growing and fast-dividing cancer cells. Since our body has many fast-growing healthy cells, chemotherapy will affect the cancer cells as well as some of the healthy cells (such as hair, skin, and the GI tract).
Fortunately, this effect is at a much lower rate and your body replenishes the cells quickly. The side-effects typically stop after you are done with treatment.
With the great advances in drug research, physicians understand the effects chemotherapy can have and will prescribe medications that will help lessen the expected symptoms.
We recommend that you take the medications as prescribed and speak to your physician or nurse if you have any questions or concerns.
Some general side-effects of chemotherapy are as follows:
*Not all side effects are listed above. Talk to your healthcare team if you experience side effects from your immunotherapy. Do not wait until symptoms become severe. In many cases, medications to suppress your immune system can be given to help reduce the side effects. For more information on possible side effects of immunotherapy,
www.chemocare.com.
Targeted Therapy
Targeted therapies are a class of anti-cancer medications that are used to treat HER2+ breast cancers. Through research, drug development, and clinical trials, we have been able to learn more about the changes in cells that cause cancer and the drugs that target them. These newer drugs are not a type of chemotherapy but are a “targeted therapy” that specifically targets those changes in cells.
Your medical oncologist will weigh many factors to determine if you will need targeted therapy or not:
Targeted therapy is given through an intravenous line the same way chemotherapy is given, and it treats the body systemically, killing cancer cells throughout the body. It is typically used in combination with chemotherapy or another targeted therapy and can be continued after chemotherapy is completed*.
There are a variety of targeted therapies that are available to treat breast cancer today. The type of medication(s) and duration of treatment will vary based on your unique situation. Your medical oncologist will determine what treatment(s) is best for you.
For women with a metastatic hormone receptor-positive (estrogen-receptor positive and/or progesterone receptor positive) breast cancer, certain targeted therapy drugs are given in pill form and can be very beneficial to help stop or slow cancer growth.
These medications are typically given in combination with hormone therapy.
*For more information on targeted therapy, talk to your healthcare team or visit www.chemocare.com.
Side Effects of Targeted Therapy
Your medical oncologist will discuss the possible side-effects of targeted therapy*
These side-effects are typically mild, but there are some rare side-effects your physician will review with you:
*Targeted therapies are not indicated for women who are pregnant. If you are of child bearing age, talk to your medical oncologist about using effective birth control if you are prescribed these medications. Not all side effects are listed above. For more information on the possible side effects of targeted therapy, visit www.chemocare.com.
Immunotherapy
Immunotherapy is a type of biological therapy that helps boost your immune system to fight cancer. Drugs such as Pembrolizumab (Keytruda) are often used in combination with chemotherapy to treat cancer that cannot be removed with surgery (unresectable), triple positive breast cancer (TPBC) that has spread beyond the breast to other parts of the body or are PD-L1 positive.
Specific eligibility criteria must be met for these drugs and your medical oncologist will help determine which treatment options are best for you.
Side Effects of Immunotherapy
Some of the possible side effects of immunotherapy include:
*Not all side ef ects are listed above. Talk to your healthcare team if you experience side effects from your immunotherapy. Do not wait until symptoms become severe. In many cases, medications to suppress your immune system can be given to help reduce the side effects. For more information on possible side ef ects of immunotherapy, visit www.chemocare.com.
Radiation Therapy
Radiation therapy is a local cancer treatment that uses high energy x-rays to kill cancer cells and shrink tumors. If you are a candidate for this type of treatment, you will be referred to a radiation oncologist, a physician who treats cancer with radiation therapy.
The radiation oncologist will likely recommend treatment based on several factors:
Radiation therapy is an outpatient procedure that typically starts after your surgical wound has healed (roughly 4 weeks). The radiation oncologist will set up a treatment plan specially designed for you through careful planning and mapping.
During this planning stage, you will be given special skin markings, which will aid in proper positioning for daily treatments. Radiation is given daily, Monday through Friday, for 3-6 weeks and each treatment takes only 10-15 minutes.
Side Effects of Radiation Therapy
Radiation therapy can have short-term side effects from treatment which typically resolve within two weeks of completing treatment:
Radiation therapy can have long-term side effects from treatment:
Radiation therapy can have rare side effects from treatment:
If you have any questions or concerns or experience any of these side effects, talk to your radiation oncologist or nurse. They can explain more about your risk factors during treatment and recommended treatments to manage the symptoms.
Some women have a family history of breast, ovarian, colon, or pancreatic cancer and may be at a higher risk of developing a second cancer (in the same or opposite breast) or another type of cancer during their lifetime due to gene mutations in their DNA.
Your physician will review your heredity cancer risk at the time of your consultation and determine if you meet the guidelines for genetic testing.
There are a variety of sophisticated genetic tests available today that are performed by obtaining a sample of your blood or saliva. The test contains a panel of genes with each gene carrying a different risk for future cancers.
According to the American Cancer Society, the most common type of hereditary breast cancer is found in the BRCA1 or BRCA2 gene. Women with one of these mutations is not only more likely to develop breast cancer in her lifetime, but also at a younger age as well as to have cancer in both breasts. She is also at a higher risk to develop ovarian and other cancers in her lifetime.
If an inherited gene is found, treatment options can become more complex and the patient should consult with their healthcare team about the current guidelines of care.
Keep in mind that not everyone who carries a gene mutation develops breast or ovarian cancer.
Many patients with metastatic breast cancer gain great benefit from participating in a clinical trial study. During these studies, patients are able to receive novel (new) therapies to treat their cancer before they become FDA approved.
Clinical trials study new drug treatments and differ from normal care. These trials are usually sponsored by large organizations, such as drug companies, to collect and analyze data that lead to new treatments for metastatic breast cancer patients. This opportunity can offer real hope for metastatic breast cancer patients.
The benefit of participating in a drug study is that you will be a part of the research process and get access to tomorrow’s treatment today. Should you be interested in taking part in a clinical trial, you must meet the eligibility requirements of the study and sign a consent form prior to participation.
At South Texas Oncology and Hematology, our mission is to provide the highest quality care for people with cancer and help accelerate the development of new treatments in order to improve patients’ quality of life and give them real hope against cancer.
In pursuit of this mission, South Texas Oncology and Hematology provides world-class care, with multiple convenient locations in San Antonio and across the globe.
Comprised of a large team of caring, dedicated cancer doctors, South Texas Oncology and Hematology combines excellent people, state-of-the-art capabilities and the most advanced treatments available.
We bring together multiple cancer-care specialties and modalities — surgery, chemotherapy, radiation therapy, immunotherapy, integrative therapies, genetic testing of tumors — for thorough and efficient care. In addition, we make an uncommon commitment to advancing the standard of cancer care through our leadership role in cancer research.
According to the American Cancer Society, there is no way to prevent a recurrence of cancer, but there are things that you can do to decrease your chances of a recurrence:
After cancer treatment is completed, your healthcare team will set-up a post-treatment follow-up or survivorship care plan with you. The goal of this plan is to provide patients with an individualized care plan that addresses follow-up visits as well as long-term side effects of cancer and its treatments.
Each team will have their own set of guidelines for follow-up care, so talk to them individually to establish a plan for your post-treatment needs.
Some of the services that can be expected during your follow-up care include:
Images:
https://www.healthywomen.org/condition/breast-cancer/types-of-breast-cancer
https://hlp.nucleushealth.com/lumpectomy-and-mastectomy-appearance-after-surgery/view-item?ItemID=10385
https://www.cancer.gov/publications/dictionaries/cancer-terms/def/sentinel-lymph-node-biopsy
American Cancer Society:
https://www.cancer.org/content/dam/cancer-org/research/cancer-facts-and-statistics/breast-cancer-facts-and-figures/breast-cancer-facts-and-figures-2019-2020.pdf
https://www.cancer.org/cancer/breast-cancer/risk-and-prevention.html
https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/breast-cancer-risk-factors-you-cannot-change.html
https://www.cancer.org/cancer/breast-cancer.html
https://www.cancer.org/cancer/breast-cancer/risk-and-prevention/can-i-lower-my-risk.html
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